Yes. A direct EB-5 investment in a new commercial enterprise the investor owns and manages is permitted, provided the qualifying capital is invested and at risk, at least ten full-time jobs for qualifying US workers are created, and he engages in management. The difference from a regional centre is that only direct jobs count.
Direct investment means direct jobs and direct management
The regional-centre programme allows indirect and induced jobs computed by economic modelling; a direct investor must count actual employees on the enterprise's payroll. Hypothetical example: a Lake Country contractor's Arizona plant plans to hire assembly technicians, a plant supervisor, a quality inspector, a logistics coordinator and office staff, totalling twelve full-time positions within two years; each must be a qualifying US worker working at least 35 hours a week, and the contractor and his family are excluded from the count. He must also take part in management, whether as an officer making policy or by running the plant, and the business plan should show what he will do and how often he will be present.
The capital, at the standard amount unless the site qualifies for the targeted employment area figure, must be invested in the enterprise and at risk, not held in reserve. He should verify the current amounts on the USCIS page before proceeding.